Urinary O6-methylguanine excretion in the rat after O6-methylguanine but not N-methylnitrosourea administration.

Abstract

Urinary makers that permit monitoring the exposure of rats to methylating carcinogens could be of considerable value. Because of the association of the formation and retention of O6-methylguanine (m6Gua) with carcinogenesis, the urinary recovery of this compound would be of particular interest. Urine of rats receiving 200 muCi 3H-methyl nitrosourea (MNU… (More)

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