Urinary O6-methylguanine excretion in the rat after O6-methylguanine but not N-methylnitrosourea administration.


Urinary makers that permit monitoring the exposure of rats to methylating carcinogens could be of considerable value. Because of the association of the formation and retention of O6-methylguanine (m6Gua) with carcinogenesis, the urinary recovery of this compound would be of particular interest. Urine of rats receiving 200 muCi 3H-methyl nitrosourea (MNU… (More)


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