Urinary N-acetyl-S-2-hydroxyethyl-L-cysteine in rats as biological indicator of ethylene oxide exposure.

@article{Gerin1986UrinaryNI,
  title={Urinary N-acetyl-S-2-hydroxyethyl-L-cysteine in rats as biological indicator of ethylene oxide exposure.},
  author={Michel G. Gerin and Robert Tardif},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1986},
  volume={7 3},
  pages={419-23}
}
There is no simple method known for the biological monitoring of ethylene oxide exposure. N-Acetyl-S-2-hydroxyethyl-L-cysteine (2-hydroxyethylmercapturic acid) excretion was evaluated as a potential indicator of exposure to this gas. Groups of Sprague-Dawley rats were given iv doses of 1, 10, or 100 mg/kg of ethylene oxide dissolved in water. Urines were collected after 12 and 24 hr. In another experiment groups of Sprague-Dawley rats were exposed by inhalation to concentrations of 1, 5, 10, 25… CONTINUE READING