Urinary MMP-2 and MMP-9 predict the presence of ovarian cancer in women with normal CA125 levels.

@article{Coticchia2011UrinaryMA,
  title={Urinary MMP-2 and MMP-9 predict the presence of ovarian cancer in women with normal CA125 levels.},
  author={Christine M Coticchia and Adam S Curatolo and David Zurakowski and Jiang Yong Yang and Kathryn E Daniels and Ursula A. Matulonis and Marsha A Moses},
  journal={Gynecologic oncology},
  year={2011},
  volume={123 2},
  pages={295-300}
}
OBJECTIVE To determine whether urinary matrix metalloproteinases (MMPs) predict the presence of ovarian cancer in patients with CA125 levels below the normal threshold of 35U/mL, a critical group of patients for whom no ovarian cancer biomarker is currently available. To determine whether these noninvasive biomarkers provide clinically useful information in the general ovarian cancer patient population as well. METHODS ELISA analyses and substrate gel electrophoresis detected the levels and… CONTINUE READING
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