Urinary Isoprostane Levels and Age-Related Macular Degeneration.

  title={Urinary Isoprostane Levels and Age-Related Macular Degeneration.},
  author={Charumathi Sabanayagam and Weng Kit Lye and Andrzej S Januszewski and Riswana Banu Binte Mohammed Abdul and Gemmy Chui Ming Cheung and N. Vijaya Kumari and Tien Yin Wong and Ching-Yu Cheng and Ecosse L Lamoureux},
  journal={Investigative ophthalmology & visual science},
  volume={58 5},
Purpose Oxidative stress, characterized by an excessive production of reactive oxygen intermediates has been suggested to play a role in the pathogenesis of age-related macular degeneration (AMD). We examined the association of urinary F2-isoprostanes (F2-IsoPs), a marker of lipid peroxidation and the most reliable marker of oxidative damage with AMD. Methods We included 238 adults with AMD and 390 age- and sex-matched controls without AMD who participated in a population-based cross… CONTINUE READING