Urinary Exosomes Contain MicroRNAs Capable of Paracrine Modulation of Tubular Transporters in Kidney

@inproceedings{Gracia2017UrinaryEC,
  title={Urinary Exosomes Contain MicroRNAs Capable of Paracrine Modulation of Tubular Transporters in Kidney},
  author={Tannia Gracia and Xueding Wang and Ya Su and Elizabeth E. Norgett and Timothy L. Williams and Pablo Moreno and Gos Micklem and Fiona E. Karet Frankl},
  booktitle={Scientific reports},
  year={2017}
}
Exosomes derived from all nephron segments are present in human urine, where their functionality is incompletely understood. Most studies have focused on biomarker discovery rather than exosome function. Through sequencing we identified the miRNA repertoire of urinary exosomes from healthy volunteers; 276 mature miRNAs and 345 pre-miRNAs were identified (43%/7% of reads). Among the most abundant were members of the miR-10, miR-30 and let-7 families. Targets for the identified miRNAs were… CONTINUE READING

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