Urinary Excretion Contributes to Long-Lasting Blockade of Bladder Muscarinic Receptors by Imidafenacin: Effect of Bilateral Ureteral Ligation.

@article{Ito2016UrinaryEC,
  title={Urinary Excretion Contributes to Long-Lasting Blockade of Bladder Muscarinic Receptors by Imidafenacin: Effect of Bilateral Ureteral Ligation.},
  author={Yoshihiko Ito and Shiori Kuraoka and Soma Endo and Ayaka Takahashi and Satomi Onoue and Shizuo Yamada},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2016},
  volume={360 1},
  pages={
          69-74
        }
}
Imidafenacin is a potent and selective antagonist of M1 and M3 muscarinic receptors that is safe, efficacious, and well tolerated for controlling the symptoms of overactive bladder (OAB). However, the precise mechanisms responsible for the bladder-selective pharmacological effects of this agent remain unclear. The in vivo pharmacologic effects of imidafenacin result from receptor occupancy. Therefore, the present study was performed to characterize in vivo muscarinic receptor binding by tritium… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 16 REFERENCES

imidafenacin in rats by positron emission tomography

A Yoshida, Y Kuraoka S. Ito, +7 authors S Yamada
  • Life Sci
  • 2014
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine

S Maruyama, N Hasuike, K Suzuki, S Yamada
  • Curr Med Chem
  • 2008
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

imidafenasin, to treat overactive bladder

S Yamamoto, S Maruyama, +5 authors H Tsukada
  • J Pharmacol Exp Ther
  • 2011
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

antimuscarinic agent, assessed by using an effectiveness index for bladder capacity in rats

A Yoshida, T Fujino, +3 authors S Yamada
  • Naunyn Schmiedebergs Arch Pharmacol
  • 2010
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

3H]imidafenacin in the human bladder and parotid gland

M Zaitsu, K Mikami, N Ishida, T Takeuchi
  • J Pharmacol Sci
  • 2011
VIEW 1 EXCERPT

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