Urinary C4d does not correlate with C4d-staining in peritubular capillaries but reflects nonspecific glomerular injury.

@article{Hoenger2008UrinaryCD,
  title={Urinary C4d does not correlate with C4d-staining in peritubular capillaries but reflects nonspecific glomerular injury.},
  author={Gideon Hoenger and Michael J. Mayr and Michael Jan Dickenmann and Michael J{\"o}rg Mihatsch and S Schaub},
  journal={Transplantation},
  year={2008},
  volume={85 4},
  pages={542-6}
}
BACKGROUND C4d-staining in peritubular capillaries (PTC) in allograft biopsies is a hallmark of antibody-mediated rejection (AMR). This study investigated whether urinary C4d correlates with C4d-staining in PTC, allowing for a noninvasive screening procedure. METHODS Urine samples from 34 patients with diffuse C4d-staining in PTC (C4d-pos group) and 68 urine samples from patients with negative C4d-staining in PTC (C4d-negative group) matched 1:2 according to proteinuria and time… CONTINUE READING
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