Urinary Bladder Function and Somatic Sensitivity in Vasoactive Intestinal Polypeptide (VIP)−/− Mice

@article{Studeny2008UrinaryBF,
  title={Urinary Bladder Function and Somatic Sensitivity in Vasoactive Intestinal Polypeptide (VIP)−/− Mice},
  author={Simon Studeny and Bopaiah P. Cheppudira and Susan A Meyers and Elena M. Balestreire and Gerard A. Apodaca and Lori Ann Birder and Karen M. Braas and James A. Waschek and Victor May and Margaret A Vizzard},
  journal={Journal of Molecular Neuroscience},
  year={2008},
  volume={36},
  pages={175-187}
}
Vasoactive intestinal polypeptide (VIP) is an immunomodulatory neuropeptide widely distributed in neural pathways that regulate micturition. VIP is also an endogenous anti-inflammatory agent that has been suggested for the development of therapies for inflammatory disorders. In the present study, we examined urinary bladder function and hindpaw and pelvic sensitivity in VIP−/− and littermate wildtype (WT) controls. We demonstrated increased bladder mass and fewer but larger urine spots on… CONTINUE READING
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