Urinary ATP Synthase Subunit β Is a Novel Biomarker of Renal Mitochondrial Dysfunction in Acute Kidney Injury.

@article{Whitaker2015UrinaryAS,
  title={Urinary ATP Synthase Subunit β Is a Novel Biomarker of Renal Mitochondrial Dysfunction in Acute Kidney Injury.},
  author={Ryan M. Whitaker and Midhun C. Korrapati and Lindsey Jay Stallons and Sean R. Jesinkey and John M. Arthur and Craig Cano Beeson and Zhi Zhong and Rick G Schnellmann},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2015},
  volume={145 1},
  pages={
          108-17
        }
}
Although the importance of mitochondrial dysfunction in acute kidney injury (AKI) has been documented, noninvasive early biomarkers of mitochondrial damage are needed. We examined urinary ATP synthase subunit β (ATPSβ) as a biomarker of renal mitochondrial dysfunction during AKI. Mice underwent sham surgery or varying degrees (5, 10, or 15 min ischemia) of ischemia/reperfusion (I/R)-induced AKI. Serum creatinine, BUN, and neutrophil gelatinase-associated lipocalin were elevated only in the 15… CONTINUE READING
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