Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults.

@article{Gao2010Urinary8A,
  title={Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults.},
  author={Xiang Gao and C Lai and Tammy Scott and Jian Shen and Tianxi Cai and Jos{\'e} M. Ordov{\'a}s and Katherine L Tucker},
  journal={American journal of epidemiology},
  year={2010},
  volume={172 3},
  pages={271-8}
}
DNA oxidative stress has been suggested as an important pathogenic mechanism in cognitive impairment and dementia. With baseline data collected from 2004 to 2008, the authors examined whether urinary 8-hydroxy-2-deoxyguanosine (8-OHdG), a biomarker of global DNA oxidation, was associated with cognitive function in a sample of 1,003 Puerto Rican adults, aged 45-75 years, living in Boston, Massachusetts, and the surrounding area. Cognitive function was measured by using a battery of 7 tests: the… CONTINUE READING
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