Urinary 6β-Hydroxycortisol/Cortisol Ratio Most Highly Correlates With Midazolam Clearance Under Hepatic CYP3A Inhibition and Induction in Females: A Pharmacometabolomics Approach

@article{Shin2016Urinary6R,
  title={Urinary 6β-Hydroxycortisol/Cortisol Ratio Most Highly Correlates With Midazolam Clearance Under Hepatic CYP3A Inhibition and Induction in Females: A Pharmacometabolomics Approach},
  author={Kwang-Hee Shin and Li Young Ahn and Man Ho Choi and Ju-Yeon Moon and Jieon Lee and I. C. Jang and Kyung-Sang Yu and Joo Youn Cho},
  journal={The AAPS Journal},
  year={2016},
  volume={18},
  pages={1254-1261}
}
Endogenous metabolites of cytochrome P450 (CYP3A) are useful in predicting drug-drug interactions between in vivo CYP3A inhibitors and inducers for clinical applications of CYP3A substrate drugs. This study aimed to develop predictable markers of the magnitude of hepatic CYP3A induction and inhibition in healthy female subjects using pharmacometabolomics. Twelve female subjects received midazolam during three study phases: 1 mg midazolam (control phase), 1 mg midazolam after pretreatment with… CONTINUE READING
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