Urinary β-1-galactosyl-0-hydroxylysine (GH) as a marker of collagen turnover of bone

@article{Moro2007Urinary,
  title={Urinary $\beta$-1-galactosyl-0-hydroxylysine (GH) as a marker of collagen turnover of bone},
  author={L. Moro and R. S. Mucelli and C. Gazzarrini and C. Modricky and F. Marotti and B. Bernard},
  journal={Calcified Tissue International},
  year={2007},
  volume={42},
  pages={87-90}
}
Summaryβ-1-galactosyl-0-hydroxylysine (GH) was measured in the urine of 59 women and 48 men, aged 30–79 years, by High Performance Liquid Chromatography (HPLC) of the dansylated derivative. Vertebral mineral density, measured by quantitative computed tomography (QCT), and urinary GH were inversely correlated (r=−0.74;P<0.001). High rate of bone mineral loss is associated with a high urinary GH excretion. Measurement of GH in urine provides a simple and noninvasive method for the evaluation of… Expand
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References

SHOWING 1-10 OF 19 REFERENCES
[18] Urinary metabolites of collagen
Publisher Summary The urinary excretion of hydroxyproline and hydroxylysine has been a commonly used standard for the evaluation of collagen degradation. Free urinary hydroxylysine does not appear toExpand
Urinary excretion of hydroxylysine and its glycosides as an index of collagen degradation.
TLDR
In patients with Paget's disease of bone, hyperphosphatasia, and extensive thermal burns the pattern of urinary Hy1 and its glycosides was consistent with degradation of collagen in dermis and fascia, and when bone collagen degradation was dominant, the patterns of urinary metabolites reflected that source. Expand
Variations in human urinary O-hydroxylysyl glycoside levels and their relationship to collagen metabolism.
TLDR
Urinary O-hydroxylysyl glycoside excretion, in addition to providing a more quantitative estimate of collagen turnover than urinary hydroxyproline, may prove to be of value as a specific means of studying the metabolism of bone collagen. Expand
The quantitative relationship of urinary peptide hydroxyproline excretion to collagen degradation.
TLDR
It is suggested that urinary hydroxyproline excretion is a "fairly" sensitive indicator of collagen breakdown and can be used at the clinical level to quantitate changes in collagen breakdown. Expand
Bone mass as referent for urinary hydroxyproline excretion: Age and sex-related changes in 125 normals and in primary hyperparathyroidism
TLDR
Estimation of bone resorption by use of OHPr:Cr requires adjustment for differences in bone mass, as shown in patients with primary hyperparathyroidism and in post-menopausal females. Expand
High-performance liquid chromatographic analysis of urinary hydroxylysyl glycosides as indicators of collagen turnover.
Description d'une methode rapide et sensible, impliquant la conversion des groupes amines de l'hydroxylysine en derives fluorescents a l'aide du chlorure de dansyle, avant la separation parExpand
Modifications of a specific assay for hydroxyproline in urine.
Abstract Several modifications of a specific chemical assay for hydroxyproline in urine are presented which make the procedure more rapid without reducing its specificity or accuracy. Also, a newExpand
Quantitative Computed Tomography of Vertebral Spongiosa: A Sensitive Method for Detecting Early Bone Loss After Oophorectomy
TLDR
The results indicate that spinal quantitative computed tomography provides a highly sensitive measurement of bone mineral loss after oophorectomy, that bone Mineral loss is five- to sevenfold greater from the spinal spongiosum than from the appendicular cortex, and that conjugated estrogen in doses of less than 0.6 mg/d are inadequate to prevent the vertebral mineral loss. Expand
Quantitative computed tomography for prediction of vertebral fracture risk.
TLDR
Vertebral compression fractures or wedging was generally absent in patients with vertebral mineral values above 110 mg cm-3, whereas almost all patients with values below 65 mgcm-3 had fractures. Expand
Low-dose CT scanning for quantitative spinal mineral analysis.
TLDR
The effect of x-ray exposure on the precision of quantitative CT bone mineral measurements was determined using excised vertebrae and phantoms using the UCSF/GE research scanner, a modified GE CT/T 7800. Expand
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