Uridylation of mature miRNAs and siRNAs by the MUT68 nucleotidyltransferase promotes their degradation in Chlamydomonas.

@article{Ibrahim2010UridylationOM,
  title={Uridylation of mature miRNAs and siRNAs by the MUT68 nucleotidyltransferase promotes their degradation in Chlamydomonas.},
  author={Fadia Ibrahim and Linda A. Rymarquis and E A Kim and James C. Becker and Eniko Balassa and Pamela J. Green and Heriberto D. Cerutti},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 8},
  pages={3906-11}
}
Regulation of gene expression by small RNAs ( approximately 20-30 nucleotides in length) plays an essential role in developmental pathways and defense responses against genomic parasites in eukaryotes. MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) commonly direct the inactivation of cognate sequences through a variety of mechanisms, including RNA degradation, translation inhibition, and transcriptional repression. Recent studies have provided considerable insight into the biogenesis… CONTINUE READING