Uridine reduces rotation induced by L-dopa and methamphetamine in 6-OHDA-treated rats.

@article{Myers1995UridineRR,
  title={Uridine reduces rotation induced by L-dopa and methamphetamine in 6-OHDA-treated rats.},
  author={C S Myers and Hans Fisher and George W. Wagner},
  journal={Pharmacology, biochemistry, and behavior},
  year={1995},
  volume={52 4},
  pages={749-53}
}
The pyrimidine nucleoside uridine may reduce side effects associated with antipsychotic medication by interacting with dopamine or GABA neurotransmission. Male Sprague-Dawley rats were used to investigate coadministration of uridine with agents that alter food intake (amphetamine, haloperidol, and chlordiazepoxide) and locomotor activity (methamphetamine and L-dopa). Results indicated that chronic uridine [32.0 mg/kg, intraperitoneally (IP)] alone did not alter milk intake or reduction of milk… CONTINUE READING

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