Uridine receptor: discovery and its involvement in sleep mechanism.

  title={Uridine receptor: discovery and its involvement in sleep mechanism.},
  author={T. Kimura and I. Ho and I. Yamamoto},
  volume={24 3},
  • T. Kimura, I. Ho, I. Yamamoto
  • Published 2001
  • Chemistry, Medicine
  • Sleep
  • This review deals with the concept of sleep mechanism based on our uridine receptor theory. It is well established that uridine is one of the sleep-promoting substances, we have, therefore, synthesized new types of hypnotic compounds from oxopyrimidine nucleosides. Their mechanism of action in CNS depressant effects is elucidated based on the receptor theory. In this study, structure-activity relationship for CNS depressant properties, sleep-promoting effects, interaction with certain CNS… CONTINUE READING
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