Uridine modulates neuronal activity and inhibits spike-wave discharges of absence epileptic Long Evans and Wistar Albino Glaxo/Rijswijk rats.

@article{Kovcs2013UridineMN,
  title={Uridine modulates neuronal activity and inhibits spike-wave discharges of absence epileptic Long Evans and Wistar Albino Glaxo/Rijswijk rats.},
  author={Zsolt Kov{\'a}cs and Andrea Sl{\'e}zia and Zsolt Krist{\'o}f Bali and Peter Kovacs and {\'A}rp{\'a}d Dobolyi and Tam{\'a}s Szikra and Istv{\'a}n Hern{\'a}di and G{\'a}bor Juh{\'a}sz},
  journal={Brain research bulletin},
  year={2013},
  volume={97},
  pages={16-23}
}
Pharmacological and functional data suggest the existence of uridine (Urd) receptors in the central nervous system (CNS). In the present study, simultaneous extracellular single unit recording and microiontophoretic injection of the pyrimidine nucleoside Urd was used to provide evidence for the presence of Urd-sensitive neurons in the thalamus and the cerebral cortex of Long Evans rats. Twenty-two neurons in the thalamus (24% of recorded neurons) and 17 neurons in the cortex (55%) responded to… CONTINUE READING

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