Uridine function in the central nervous system.

  title={Uridine function in the central nervous system.},
  author={{\'A}rp{\'a}d Dobolyi and G{\'a}bor Juh{\'a}sz and Zsolt Kov{\'a}cs and Julianna Kardos},
  journal={Current topics in medicinal chemistry},
  volume={11 8},
In the adult nervous system, the major source of nucleotide synthesis is the salvage pathway. Uridine is the major form of pyrimidine nucleosides taken up by the brain. Uridine is phosphorylated to nucleotides, which are used for DNA and RNA synthesis as well as for the synthesis of membrane constituents and glycosylation. Uridine nucleotides and UDP-sugars may be released from neuronal and glial cells. Plasmamembrane receptors of 7 transmembrane domains have been identified that recognize UTP… 

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