Uridine catabolism by the isolated perfused rat liver.


A new approach in the treatment of gastrointestinal tumors with 5-fluorouracil involves the infusion of high doses of uridine to improve the chemotherapeutic efficiency of the former. High amounts of uracil formed from uridine can interfere with the hepatic catabolism of 5-fluorouracil and thus increase its bioavailability and toxicity. In our study, we… (More)


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@article{Holstege1992UridineCB, title={Uridine catabolism by the isolated perfused rat liver.}, author={Axel Holstege and H M Gengenbacher and L S Jehle and Wolfgang Gerok}, journal={Journal of hepatology}, year={1992}, volume={14 2-3}, pages={335-41} }