Uric acid modulates vascular endothelial function through the down regulation of nitric oxide production.

@article{Papekov2013UricAM,
  title={Uric acid modulates vascular endothelial function through the down regulation of nitric oxide production.},
  author={Ivana Pape{\vz}{\'i}kov{\'a} and Michaela Pekarov{\'a} and Hana Kol{\'a}řov{\'a} and Anna Klinke and Denise Lau and Stephan Baldus and Anton{\'i}n Lojek and Luk{\'a}{\vs} Kubala},
  journal={Free radical research},
  year={2013},
  volume={47 2},
  pages={82-8}
}
Endothelial dysfunction characterized by decreased nitric oxide (NO) bioavailability is the first stage of coronary artery disease. It is known that one of the factors associated with an increased risk of coronary artery disease is a high plasma level of uric acid. However, causative associations between hyperuricaemia and cardiovascular risk have not been definitely proved. In this work, we tested the effect of uric acid on endothelial NO bioavailability. Electrochemical measurement of NO… CONTINUE READING
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