Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.

@article{Gasse2009UricAI,
  title={Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.},
  author={Pam{\'e}la Gasse and Nicolas Riteau and Sabine Charron and Sandra Girre and Lizette Fick and Virginie P{\'e}trilli and J. -M. Tschopp and Vincent Lagente and Val{\'e}rie F J Quesniaux and Bernhard Ryffel and Isabelle Couillin},
  journal={American journal of respiratory and critical care medicine},
  year={2009},
  volume={179 10},
  pages={903-13}
}
RATIONALE Lung injury leads to pulmonary inflammation and fibrosis through myeloid differentiation primary response gene 88 (MyD88) and the IL-1 receptor 1 (IL-1R1) signaling pathway. The molecular mechanisms by which lung injury triggers IL-1beta production, inflammation, and fibrosis remain poorly understood. OBJECTIVES To determine if lung injury depends on the NALP3 inflammasome and if bleomycin (BLM)-induced lung injury triggers local production of uric acid, thereby activating the NALP3… CONTINUE READING
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