Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter.

@article{Kang2005UricAC,
  title={Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter.},
  author={Duk-Hee Kang and Lin Han and Xiaosen Ouyang and Andrew M. Kahn and John Kanellis and Ping Li and Lili Feng and Takahiko Nakagawa and Susumu Watanabe and Makoto Hosoyamada and Hitoshi Endou and Michael Lipkowitz and Ruth H Abramson and Wei Mu and Richard J Johnson},
  journal={American journal of nephrology},
  year={2005},
  volume={25 5},
  pages={425-33}
}
BACKGROUND Soluble uric acid stimulates vascular smooth muscle cell (VSMC) proliferation by activating mitogen-activated protein kinases, and stimulating COX-2 and PDGF synthesis. The mechanism by which uric acid enters the VSMC is not known. We hypothesized that uric acid enters via transporters similar to that observed in the kidney. METHODS We studied the uptake of uric acid into rat VSMC under polarized and depolarized conditions and in the presence of organic anion transport (OAT… CONTINUE READING
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