Uric acid as radical scavenger and antioxidant in the heart

@article{Becker1989UricAA,
  title={Uric acid as radical scavenger and antioxidant in the heart},
  author={Bernhard Friedrich Becker and N. Reinholz and Tayfun {\"O}zçelik and B. Leipert and Eckehart Gerlach},
  journal={Pfl{\"u}gers Archiv},
  year={1989},
  volume={415},
  pages={127-135}
}
Uric acid (UA) is released from the heart of many species, including man, and its site of formation has been shown to be the microvascular endothelium. Since UA reacts with oxygen radicals in vitro, experiments were conducted on guinea pig hearts perfused with Krebs-Henseleit buffer (KHB) to evaluate whether the formation of UA could afford protection from damage by radicals and oxidants. The following results were obtained: (1) Upon addition of the hydroxyl radical scavenger DMSO to the… CONTINUE READING