Uric acid as a CNS antioxidant.

  title={Uric acid as a CNS antioxidant.},
  author={Gene L. Bowman and Jackilen Shannon and Balz Frei and Jeffrey A. Kaye and Joseph F Quinn},
  journal={Journal of Alzheimer's disease : JAD},
  volume={19 4},
Oxidative damage is a consistent finding in a number of central nervous system (CNS) disorders. Uric acid (UA) is a potent hydrophilic antioxidant that is modified by diet and drug. Several lines of evidence suggest that plasma UA may modulate outcomes in neurologic disease, but little attention has been paid to CNS levels of UA. Our objective was to test the hypothesis that cerebrospinal fluid (CSF) UA is determined by plasma UA, modified by blood-brain barrier (BBB) integrity and associated… CONTINUE READING


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