Uremic cardiomyopathy: role of circulating digitalis like substances.

@article{Mohmand2005UremicCR,
  title={Uremic cardiomyopathy: role of circulating digitalis like substances.},
  author={Behram Mohmand and Deepak Malhotra and Joseph I. Shapiro},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2005},
  volume={10},
  pages={
          2036-44
        }
}
Patients with chronic renal failure develop a cardiomyopathy characterized by marked diastolic dysfunction and left ventricular hypertrophy. Interestingly, they also have substantial increases in the circulating concentrations of digitalis like substances. Digitalis like substances produce reactive oxygen species as part of the signal cascade induced by binding to the sodium pump and patients, and this signal cascade appears to induce hypertrophy of cardiac myocytes grown in culture. Also… 
28 Cardiotonic Steroids and Cardiac Fibrosis
It is well known and has been shown that patients who have chronic renal failure tend to develop and die of cardiac causes. These patients are known to develop a cardiomyopathy that is characterized
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TLDR
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