Uremic acidosis and protein metabolism.

  • William E. Mitch
  • Published 1995 in Current opinion in nephrology and hypertension


Mechanisms causing loss of lean body mass in uremia include an inability to activate metabolic adaptations to a low-protein diet caused by anorexia, or other factors. The adaptations include decreased degradation of essential amino acids and protein. Metabolic acidosis activates specific pathways which increase catabolism by mechanisms that include… (More)


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