Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes

@inproceedings{Horta2016UreaseIO,
  title={Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes},
  author={L{\'i}via Pereira Horta and Yane C. C. Mota and Gisele Maria Barbosa and Taniris Cafiero Braga and Ivanildo Ev{\'o}dio Marriel and {\^A}ngelo de F{\'a}tima and Luzia Valentina Modolo},
  year={2016}
}
The plant phenolic natural products (PNPs) protocatechuic aldehyde, syringaldehyde and vanillin were used as platforms for obtaining four urease inhibitors. Urea (urease substrate) or thiourea (urease inhibitor) core was added to the structure of newly synthesized compounds to provide inhibitors up to 230-fold more active than the PNPs they originated from. The PNP derivatives are mixed inhibitors with higher affinity to urease active site. Two compounds were as efficient as N-(butyl… CONTINUE READING