Urea metabolism in chronic renal failure.

@article{Walser1974UreaMI,
  title={Urea metabolism in chronic renal failure.},
  author={Mackenzie Walser},
  journal={The Journal of clinical investigation},
  year={1974},
  volume={53 5},
  pages={
          1385-92
        }
}
Urea degradation was measured during 16 experiments in 13 chronic uremic patients being treated with essential amino acids or their analogues. [(14)C]Urea was injected i.v. and the clearance of labeled urea from its volume of distribution was compared with the simultaneous renal clearance of ordinary urea, which averaged 2.0 liters/day. The difference, extrarenal clearance of urea, averaged 3.1 liters/day as compared with a previously reported mean of 18 liters/day in normal subjects. Thus urea… CONTINUE READING
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