Urea kinetics and dialysis treatment time predict vancomycin elimination during high-flux hemodialysis.

@article{Schaedeli1998UreaKA,
  title={Urea kinetics and dialysis treatment time predict vancomycin elimination during high-flux hemodialysis.},
  author={Franziska Schaedeli and Dr. E. Uehlinger},
  journal={Clinical pharmacology and therapeutics},
  year={1998},
  volume={63 1},
  pages={
          26-38
        }
}
BACKGROUND Hemodialysis sessions with high-flux filters ask for a reconsideration of the kinetics of xenobiotics. The aim of this study was to analyze whether individual high-flux hemodialysis treatment parameters are of predictive value for dosing guidelines, with use of vancomycin as a model compound. METHODS Twenty-six patients receiving high-flux hemodialysis were studied prospectively. After an intravenous infusion of 1000 mg or 500 mg vancomycin, respectively, six to eight blood samples… CONTINUE READING
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