Urea enhances the nerve growth factor-induced neuroprotective effect on cholinergic neurons in organotypic rat brain slices

@article{Zassler2005UreaET,
  title={Urea enhances the nerve growth factor-induced neuroprotective effect on cholinergic neurons in organotypic rat brain slices},
  author={Birgit Zassler and Georg Dechant and Christian Humpel},
  journal={Neuroscience},
  year={2005},
  volume={130},
  pages={317-323}
}

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TLDR
In conclusion, NGF is the most potent growth factor for cholinergic neurons and is a promising candidate for treating Alzheimers disease, however, the delivery of NGF to the brain must the solved.

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TLDR
Rapid suppression by NGF of basal and glutamate-stimulated NOS activity may regulate neuromodulatory functions of NO or protect neurons from NO toxicity and suggests a novel mechanism for rapidly mediating functions of NGF and other neurotrophins.

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TLDR
The results indicate that brain NOS can be regulated by a neurotrophic factor and suggest that NGF influences forebrain function by regulating production of nitric oxide as well as acetylcholine.

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TLDR
Treatment of cultured rat embryonic basal forebrain neurons with anti-c-fos, prior to administering NGF, blocked NGF-mediated increases in ChAT activity by 67%; basal Chat activity was not affected by the antisense oligonucleotide treatment, and Reverse transcription-polymerase chain reaction revealed that anti- c- fos treatment resulted in not only blockade but enhancement of steady-state ChAT mRNA at different time points.