Urea as a selective inhibitor of argininosuccinate lyase.

  title={Urea as a selective inhibitor of argininosuccinate lyase.},
  author={J. Menyh{\'a}rt and J. Gr{\'o}f},
  journal={European journal of biochemistry},
  volume={75 2},
The effect of urea on various ornithine cycle enzymes has been investigated. It was demonstrated that argininosuccinate lyase was the only ornithine cycle enzyme inhibited by urea in a competitive manner. Based on the data presented the possible role of urea in maintaining a physiological range of intracellular and extracellular urea concentration by controlling hepatic ureogenesis was discussed. 
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