UreE stimulation of GTP-dependent urease activation in the UreD-UreF-UreG-urease apoprotein complex.

@article{Soriano2000UreESO,
  title={UreE stimulation of GTP-dependent urease activation in the UreD-UreF-UreG-urease apoprotein complex.},
  author={Aroa Soriano and Gerard J. Colpas and Robert P. Hausinger},
  journal={Biochemistry},
  year={2000},
  volume={39 40},
  pages={12435-40}
}
The activation of metal-containing enzymes often requires the participation of accessory proteins whose roles are poorly understood. In the case of Klebsiella aerogenes urease, a nickel-containing enzyme, metallocenter assembly requires UreD, UreF, and UreG acting as a protein chaperone complex and UreE serving as a nickel metallochaperone. Urease apoprotein within the UreD-UreF-UreG-urease apoprotein complex is activated to wild-type enzyme activity levels under physiologically relevant… CONTINUE READING
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