Urbanization elicits a more atherogenic lipoprotein profile in carriers of the apolipoprotein A-IV-2 allele than in A-IV-1 homozygotes.

@article{Campos1997UrbanizationEA,
  title={Urbanization elicits a more atherogenic lipoprotein profile in carriers of the apolipoprotein A-IV-2 allele than in A-IV-1 homozygotes.},
  author={Hannia Campos and Jose L{\'o}pez-Miranda and Claudia Rodr{\'i}guez and Marta Albajar and Ernst J. Schaefer and Jos{\'e} M. Ordov{\'a}s},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1997},
  volume={17 6},
  pages={1074-81}
}
Coronary heart disease (CHD) is increasing in developing countries, particularly in urban areas. The impact of urbanization and apolipoprotein (apo) A-IV genetic polymorphism on plasma lipoproteins was studied in 222 men and 236 women from rural and urban Costa Rica. The apoA-IV allele frequencies were 0.937 for apoA-IV-1 and 0.062 for apoA-IV-2, Significant interactions between the apoA-IV polymorphism and area of residence (rural versus urban) were detected for HDL cholesterol (P = .003… CONTINUE READING

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