Urban benzene exposure and oxidative DNA damage: influence of genetic polymorphisms in metabolism genes.

@article{Srensen2003UrbanBE,
  title={Urban benzene exposure and oxidative DNA damage: influence of genetic polymorphisms in metabolism genes.},
  author={Mette Sejr S\orensen and Henrik Skov and Herman Autrup and Ole Hertel and Steffen Loft},
  journal={The Science of the total environment},
  year={2003},
  volume={309 1-3},
  pages={69-80}
}
Benzene has been implicated as an environmental risk factor in leukaemia and other haematological diseases. Relationships between urban benzene exposure, oxidative DNA damage and polymorphisms in metabolism enzymes were examined in 40 volunteers living and working in Copenhagen. Personal exposures to benzene, toluene and methyl tert-butyl ether (MTBE) were monitored during a 5-day period. DNA damage was measured by 7-hydro-8-oxo-2'-deoxyguanosine (8-oxodG) in lymphocyte DNA and urine and by… CONTINUE READING

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