Urate crystals directly activate the T-cell receptor complex and induce T-cell proliferation.

Abstract

Uric acid is a known danger associated molecular pattern molecule able to induce inflammation following internalization of its crystals by cells of the innate immune system. By activating antigen-presenting cells, urate boosts adaptive immunity as well. Furthermore, urate crystals can induce proliferation of isolated T-cells, which are unable to phagocytose… (More)
DOI: 10.3892/br.2017.960

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Cite this paper

@article{Eleftheriadis2017UrateCD, title={Urate crystals directly activate the T-cell receptor complex and induce T-cell proliferation.}, author={Theodoros Eleftheriadis and Georgios G Pissas and Maria Sounidaki and Georgia Antoniadi and Ioannis Τ. Tsialtas and Vassilios Liakopoulos and Ioannis Stefanidis}, journal={Biomedical reports}, year={2017}, volume={7 4}, pages={365-369} }