Urate and Its Transgenic Depletion Modulate Neuronal Vulnerability in a Cellular Model of Parkinson's Disease

@inproceedings{Cipriani2012UrateAI,
  title={Urate and Its Transgenic Depletion Modulate Neuronal Vulnerability in a Cellular Model of Parkinson's Disease},
  author={Sara Cipriani and Cody A. Desjardins and Thomas C. Burdett and Yuehang Xu and Kui Xu and Michael A. Schwarzschild},
  booktitle={PloS one},
  year={2012}
}
Urate is a major antioxidant as well as the enzymatic end product of purine metabolism in humans. Higher levels correlate with a reduced risk of developing Parkinson's disease (PD) and with a slower rate of PD progression. In this study we investigated the effects of modulating intracellular urate concentration on 1-methyl-4-phenyl-pyridinium (MPP(+))-induced degeneration of dopaminergic neurons in cultures of mouse ventral mesencephalon prepared to contain low (neuron-enriched cultures) or… CONTINUE READING
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