Uraemic medium causes endothelial cell dysfunction characterized by an alteration of the properties of its subendothelial matrix.

Abstract

Uraemic patients suffer from haemorrhagic disorders and accelerated atherosclerosis. To evaluate the possible role of the vessel wall in these haemostatic alterations associated with uraemia, we investigated the effect of a uraemic milieu on human endothelial cell (EC) cultures and the reactivity of the extracellular matrices (ECM) generated by these cells… (More)

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