Uracil-induced signaling pathways for DUOX-dependent gut immunity.

  title={Uracil-induced signaling pathways for DUOX-dependent gut immunity.},
  author={Kyung-Ah Lee and Boram Kim and Hyejin You and Won-Jae Lee},
  volume={9 3},
Intestinal dual oxidase (DUOX) activation is the first line of host defense against enteric infection in Drosophila. DUOX enzymatic activity is mainly controlled by phospholipase C-β (PLCβ)-dependent calcium mobilization, whereas DUOX gene expression is mainly controlled by the MEKK1-p38 mitogen-activated protein kinase pathway. Furthermore, bacterial-derived uracil molecules act as ligands for DUOX activation. However, our current understanding of uracil-induced signal transduction pathways… CONTINUE READING

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