Uracil in DNA and its processing by different DNA glycosylases.

@article{Visnes2009UracilID,
  title={Uracil in DNA and its processing by different DNA glycosylases.},
  author={Torkild Visnes and Berit Doseth and Henrik Sahlin Pettersen and Lars Hagen and Mirta M. L. Sousa and Mansour Akbari and Marit Otterlei and Bodil Merete Kavli and Geir Slupphaug and Hans Einar Krokan},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2009},
  volume={364 1517},
  pages={563-8}
}
Uracil in DNA may result from incorporation of dUMP during replication and from spontaneous or enzymatic deamination of cytosine, resulting in U:A pairs or U:G mismatches, respectively. Uracil generated by activation-induced cytosine deaminase (AID) in B cells is a normal intermediate in adaptive immunity. Five mammalian uracil-DNA glycosylases have been identified; these are mitochondrial UNG1 and nuclear UNG2, both encoded by the UNG gene, and the nuclear proteins SMUG1, TDG and MBD4. Nuclear… CONTINUE READING
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