Uracil in DNA--general mutagen, but normal intermediate in acquired immunity.

@article{Kavli2007UracilID,
  title={Uracil in DNA--general mutagen, but normal intermediate in acquired immunity.},
  author={Bodil Merete Kavli and Marit Otterlei and Geir Slupphaug and Hans Einar Krokan},
  journal={DNA repair},
  year={2007},
  volume={6 4},
  pages={505-16}
}
Deamination of cytosine in DNA results in mutagenic U:G mispairs, whereas incorporation of dUMP leads to U:A pairs that may be genotoxic directly or indirectly. In both cases, uracil is mainly removed by a uracil-DNA glycosylase (UDG) that initiates the base excision repair pathway. The major UDGs are mitochondrial UNG1 and nuclear UNG2 encoded by the UNG-gene, and nuclear SMUG1. TDG and MBD4 remove uracil from special sequence contexts, but their roles remain poorly understood. UNG2 is cell… CONTINUE READING
38 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

Similar Papers

Loading similar papers…