Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest.

@article{Selig1997UracilDG,
  title={Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest.},
  author={Luc Selig and Serge B{\'e}nichou and Mark E. Rogel and Lily I. Wu and Marie A. Vodicka and Jos{\'e}phine Sire and Richard Benarous and Michael Emerman},
  journal={Journal of virology},
  year={1997},
  volume={71 6},
  pages={4842-6}
}
The Vpr protein encoded by human immunodeficiency virus type 1 (HIV-1) is important for growth of virus in macrophages and prevents infected cells from passing into mitosis (G2 arrest). The cellular target for these functions is not known, but Vpr of HIV-1 and the related Vpr from simian immunodeficiency virus of sooty mangabeys (SIV(SM)) bind the DNA… CONTINUE READING