Upwardly mobile proteins. Workshop: the role of HMG proteins in chromatin structure, gene expression and neoplasia.

@article{Bianchi2000UpwardlyMP,
  title={Upwardly mobile proteins. Workshop: the role of HMG proteins in chromatin structure, gene expression and neoplasia.},
  author={Marco Emilio Bianchi and Monica Beltrame},
  journal={EMBO reports},
  year={2000},
  volume={1 2},
  pages={109-14}
}
High Mobility Group proteins (HMGs) are a set of chromatin proteins first identified in the 1970s because they are very abundant and run fast on SDS–PAGE. In these and other properties they resemble histones. And like histones, which have seen a resurgence of interest thanks to the discovery that their modification modulates transcription, HMGs are staging a comeback. They now appear to be important and versatile players in the same complex plot: they regulate the expression of genes in normal… CONTINUE READING