Upward synaptic scaling is dependent on neurotransmission rather than spiking

  title={Upward synaptic scaling is dependent on neurotransmission rather than spiking},
  author={Ming-fai Fong and Jonathan Paul Newman and Steve M. Potter and Peter Wenner},
  journal={Nature Communications},
Homeostatic plasticity encompasses a set of mechanisms that are thought to stabilize firing rates in neural circuits. The most widely studied form of homeostatic plasticity is upward synaptic scaling (upscaling), characterized by a multiplicative increase in the strength of excitatory synaptic inputs to a neuron as a compensatory response to chronic reductions in firing rate. While reduced spiking is thought to trigger upscaling, an alternative possibility is that reduced glutamatergic… 
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Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function.
  • G. Turrigiano
  • Biology
    Cold Spring Harbor perspectives in biology
  • 2012
A clear picture of how homeostatic feedback is structured at the molecular level has not yet emerged, but it is likely that neuronal networks likely use this complex set of regulatory mechanisms to achieve homeostasis over a wide range of temporal and spatial scales.
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The findings suggest that AMPAergic scaling triggered by blocking spiking activity or GABAA receptor transmission represents similar phenomena, supporting the idea that activity blockade triggers scaling by reducing GabAA transmission.
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AMPA Receptor Trafficking in Homeostatic Synaptic Plasticity: Functional Molecules and Signaling Cascades
The recently identified functional molecules and signaling pathways that are involved in homeostatic plasticity are reviewed, especially theHomeostatic regulation of AMPAR localization at excitatory synapses is reviewed.
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