Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response

@article{Hase2009UptakeTG,
  title={Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response},
  author={Koji Hase and Kazuya Kawano and Tomonori Nochi and Gemilson Soares Pontes and Shinji Fukuda and Masashi Ebisawa and Kazunori Kadokura and Toru Tobe and Yumiko Fujimura and Sayaka Kawano and Atsuko Yabashi and Satoshi Waguri and Gaku Nakato and Shunsuke Kimura and Takaya Murakami and Mitsutoshi Iimura and Kimiyo Hamura and Shin-ichi Fukuoka and Anson W. Lowe and Kikuji Itoh and Hiroshi Kiyono and Hiroshi Ohno},
  journal={Nature},
  year={2009},
  volume={462},
  pages={226-230}
}
The mucosal immune system forms the largest part of the entire immune system, containing about three-quarters of all lymphocytes and producing grams of secretory IgA daily to protect the mucosal surface from pathogens. To evoke the mucosal immune response, antigens on the mucosal surface must be transported across the epithelial barrier into organized lymphoid structures such as Peyer’s patches. This function, called antigen transcytosis, is mediated by specialized epithelial M cells. The… CONTINUE READING
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