Uptake of the -Lactam Precursor -Aminoadipic Acid in Penicillium chrysogenum Is Mediated by the Acidic and the General Amino Acid Permease

Abstract

External addition of the -lactam precursor -aminoadipic acid to the filamentous fungus Penicillium chrysogenum leads to an increased intracellular -aminoadipic acid concentration and an increase in penicillin production. The exact route for -aminoadipic acid uptake is not known, although the general amino acid and acidic amino acid permeases have been… (More)

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