Uptake of the Carborane Derivative of Cholesteryl Ester by Glioma Cancer Cells Is Mediated Through LDL Receptors

@article{Pan2004UptakeOT,
  title={Uptake of the Carborane Derivative of Cholesteryl Ester by Glioma Cancer Cells Is Mediated Through LDL Receptors},
  author={Guangliang Pan and Svein \Oie and D. Robert Lu},
  journal={Pharmaceutical Research},
  year={2004},
  volume={21},
  pages={1257-1262}
}
Purpose. This study was to elucidate the mechanism of cellular uptake of cholesteryl 1,12-dicarba-closo-dodecaboranel-carboxylate (BCH), a new anti-cancer carborane derivative of cholesteryl ester, by glioma cancer cells. Methods. BCH (solubilized with liposomal formulation) was incubated with SF-763 and SF-767 glioma cell lines in the presence of different amounts of monoclonal anti-LDL receptor antibody for cellular uptake studies. Various amounts of lipoprotein deficient serum (LPDS) were… CONTINUE READING

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