Uptake of technetium 99m hepatobiliary imaging agents by cultured rat hepatocytes.

@article{Lan1988UptakeOT,
  title={Uptake of technetium 99m hepatobiliary imaging agents by cultured rat hepatocytes.},
  author={J W Lan and L. Rao Chervu and Kirsten L Johansen and Allan W. Wolkoff},
  journal={Gastroenterology},
  year={1988},
  volume={95 6},
  pages={1625-31}
}
Quantitation of initial uptake of the cholescintigraphy agents, 99mTc-Lidofenin, 99mTc-Disofenin, 99mTc-Mebrofenin, and 99mTc-Arclofenin, in short-term cultured rat hepatocytes revealed a marked reduction at 4 degrees C as compared with 37 degrees C. Depletion of adenosine triphosphate by preincubation of cells in sodium azide and 2-deoxyglucose reduced initial uptake of 99mTc-Disofenin at 37 degrees C by 50% (p less than 0.05), suggesting an energy-dependent mechanism. At 37 degrees C, 99mTc… CONTINUE READING

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