Uptake of rosuvastatin by isolated rat hepatocytes: comparison with pravastatin

@article{Nezasa2003UptakeOR,
  title={Uptake of rosuvastatin by isolated rat hepatocytes: comparison with pravastatin},
  author={Ken-ichi Nezasa and Kazutaka Higaki and Masaharu Takeuchi and Masayuki Nakano and Masahiro Koike},
  journal={Xenobiotica},
  year={2003},
  volume={33},
  pages={379 - 388}
}
1. The liver is the target organ for the lipid-regulating effect of rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, and liver-selective uptake of this drug is therefore a desirable property. The uptake kinetics of rosuvastatin were investigated and compared with those of pravastatin using isolated rat hepatocytes. 2. Uptake for both drugs involved both active transport and passive diffusion processes. The Michaelis constant (K m) of uptake rate for rosuvastatin (9… 
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