Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin.

@article{Piccinotti2013UptakeOR,
  title={Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin.},
  author={Silvia Piccinotti and Tomas Kirchhausen and Sean P J Whelan},
  journal={Journal of virology},
  year={2013},
  volume={87 21},
  pages={11637-47}
}
Rabies virus (RABV) causes a fatal zoonotic encephalitis. Disease symptoms require replication and spread of the virus within neuronal cells; however, in infected animals as well as in cell culture the virus replicates in a broad range of cell types. Here we use a single-cycle RABV and a recombinant vesicular stomatitis virus (rVSV) in which the glycoprotein (G) was replaced with that of RABV (rVSV RABV G) to examine RABV uptake into the African green monkey kidney cell line BS-C-1. Combining… CONTINUE READING

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