Uptake of nerve growth factor along peripheral and spinal axons of primary sensory neurons.

@article{Richardson1984UptakeON,
  title={Uptake of nerve growth factor along peripheral and spinal axons of primary sensory neurons.},
  author={Peter M. Richardson and Richard J. Riopelle},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1984},
  volume={4 7},
  pages={1683-9}
}
To investigate the distribution of nerve growth factor (NGF) receptors on peripheral and central axons, [125I]NGF was injected into the sciatic nerve or spinal cord of adult rats. Accumulation of [125I]NGF in lumbar dorsal root ganglia was monitored by gamma emission counting and radioautography. [125I]NGF, injected endoneurially in small quantities, was taken into sensory axons by a saturable process and was transported retrogradely to their cell bodies at a maximal rate of 2.5 to 7.5 mm/hr… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 29 references

Characterization of the retrograde transport of nerve growth factor (NGF) using high specific activity iz51-NGF

E. M. Johnson, Jr., R. Y. Andres, R. A. Bradshaw
factor. Brain Res • 1978
View 3 Excerpts
Highly Influenced

Effect of exposure to antiNGF on sensory neurons of adult rats and guinea pigs

K. Stoeckel
Brain Res . • 1982

Nerve growth a & ivities in rat peripheral nerve

P. M. Richardson, U. M. McGuinness, J. Aguayo
Brain Res . 2 J • 1982
View 1 Excerpt

Biological importance of the retrograde axonal transport of nerve growth factor in sensory neurons.

Proceedings of the National Academy of Sciences of the United States of America • 1981

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