Uptake of long-circulating immunoliposomes, directed against colon adenocarcinoma cells, by liver metastases of colon cancer.

@article{Kamps2000UptakeOL,
  title={Uptake of long-circulating immunoliposomes, directed against colon adenocarcinoma cells, by liver metastases of colon cancer.},
  author={Jan A A M Kamps and Gerben A. Koning and Maria J. Velinova and Henri{\"e}tte W. M. Morselt and Marcela Wilkens and Arko Gorter and Jiazheng Donga and Gerrit L. Scherphof},
  journal={Journal of drug targeting},
  year={2000},
  volume={8 4},
  pages={235-45}
}
Radiolabeled ([3H]cholesteryloleyl ether) immunoliposomes directed against rat colon adenocarcinoma CC531 cells were prepared by random coupling of a tumor cell-specific antibody, CC52, via a thio ether bond. In vitro binding experiments demonstrated a saturable and specific interaction of CC52-immunoliposomes, which could be inhibited by free non-coupled CC52 but not by irrelevant antibodies. The in vivo targeting potential of CC52-immunoliposomes, which were pegylated to achieve prolonged… CONTINUE READING
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